Protein domain search tool

Analyze your protein sequence for Pfam matches View Pfam annotation and alignments See groups of related entries Look at the domain organisation of a protein sequence Find the domains on a PDB structure Query Pfam by keywords Go Example. Analyze your protein sequence for Pfam matches Paste your protein sequence here to find matching Pfam entries. Go Example.

View Pfam annotation and alignments Enter a entry identifier e. See groups of related families Enter a clan identifier e. View domain organisation of a protein sequence Enter a sequence identifier e.

Query Pfam by keyword Search for keywords in text data in the Pfam database. Hide this Recent Pfam blog posts. Citing Pfam If you find Pfam useful, please consider citing the reference that describes this work: Pfam: The protein families database in : J. Mistry, S. Chuguransky, L.

Williams, M. Qureshi, G. Salazar, E. Sonnhammer, S. Tosatto, L. Paladin, S. Protein domains often correspond to structural domains which are self-stabilizing and fold independently of the rest of the protein chain. They may occur independently or as part of complex multidomain protein architectures which evolve by domain accretion, domain loss or domain recombination.

Protein domains can therefore be viewed as a 'parts list' for biology. Additional information may also be found in the non-positional 'Domain' subsection. High confidence associations between a query sequence and conserved domains are shown as specific hits. Batch CD-Search serves as both a web application and a script interface for a conserved domain search on multiple protein sequences , accepting up to 4, proteins in a single job. It enables you to view a graphical display of the concise or full search result for any individual protein from your input list, or to download the results for the complete set of proteins.

Batch CD-Search Help. With either approach, the corresponding SPARCLE record s will display the name and functional label of the architecture, supporting evidence, and links to other proteins with the same architecture. Input protein sequence. Search by text word. Conserved Domain Architecture Retrieval Tool CDART performs similarity searches of the Entrez Protein database based on domain architecture, defined as the sequential order of conserved domains in protein queries.

CDART finds protein similarities across significant evolutionary distances using sensitive domain profiles rather than direct sequence similarity. Proteins similar to the query are grouped and scored by architecture.